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Pemigatinib (INCB054828)
CAS No. 1513857-77-6
Pemigatinib (INCB054828)( INCB054828 )
Catalog No. M21751 CAS No. 1513857-77-6
Pemigatinib (INCB054828) is an orally active, selective FGFR inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 87 | In Stock |
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| 10MG | 140 | In Stock |
|
| 25MG | 259 | In Stock |
|
| 50MG | 405 | In Stock |
|
| 100MG | 538 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NamePemigatinib (INCB054828)
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NoteResearch use only, not for human use.
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Brief DescriptionPemigatinib (INCB054828) is an orally active, selective FGFR inhibitor.
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DescriptionPemigatinib (INCB054828) is an orally active, selective FGFR inhibitor with IC50s of 0.4 nM, 0.5 nM, 1.2 nM, 30 nM for FGFR1, FGFR2, FGFR3, FGFR4, respectively. Pemigatinib has the potential for cholangiocarcinoma.
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In Vitro——
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In Vivo——
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SynonymsINCB054828
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PathwayAngiogenesis
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TargetFGFR
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number1513857-77-6
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Formula Weight487.5
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Molecular FormulaC??H??F?N?O?
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Purity>98% (HPLC)
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SolubilityDMSO : 25 mg/mL (51.28 mM; ultrasonic and warming and heat to 60°C)
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SMILESCCN(C(N(C(C(F)=C(OC)C=C1OC)=C1F)C2)=O)C(C2=CN3)=C4C3=NC(CN5CCOCC5)=C4
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Arudra K, et al. Calcinosis cutis dermatologic toxicity associated with fibroblast growth factor receptor inhibitor for the treatment of Wilms tumor. J Cutan Pathol. 2018 Oct;45(10):786-790.
2. Roskoski R Jr, et al. The role of fibroblast growth factor receptor (FGFR) protein-tyrosine kinase inhibitors in the treatment of cancers including those of the urinary bladder. Pharmacol Res. 2020 Jan;151:104567.
3. Krook MA, et al. Tumor heterogeneity and acquired drug resistance in FGFR2-fusion-positive cholangiocarcinoma through rapid research autopsy. Cold Spring Harb Mol Case Stud. 2019 Aug 1;5(4).
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